Tuesday, August 15, 2017

The hypoglycemic side of hypothyroidism --DIABETES--STATINS-CANCER AND MORE


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. 2014 Jan-Feb; 18(1): 1–3.
PMCID: PMC3968713

The hypoglycemic side of hypothyroidism

Hypoglycemia is a not so infrequent condition encountered in endocrine practice. Considered an inevitable (though modifiable) part of diabetes therapy, hypoglycemia occurs fairly often, in both type 1 and type 2 diabetes, in patients on oral hypoglycemic agents and insulin, and in indoor as well as outdoor settings.[] As the prevalence of diabetes rises, and as we try to control glycemia more aggressively, using the multiple permutations and combinations of antidiabetic drugs available to us, the incidence of hypoglycemia is certain to rise. Apart from this, hypoglycemia is sometimes spontaneous, and may occur without relation to antidiabetic therapy.
Hypoglycemia is basically a mismatch between insulin (whether exogenous or endogenous) and glycemic levels (whether produced by meals or parenteral nutrition). The excessive insulin levels may be due to excessive dosage, increased bioavailability, or enhanced insulin sensitivity. The inappropriate increase in insulin levels leads to a fall in blood glucose levels, which in turn stimulates a series of physiological protective mechanisms. These include a release of glucagon, adrenaline, cortisol, and growth hormone; among others.[] These physiological responses are linked with symptoms, which can be classified as adrenergic or autonomic, neuroglycopenic, and general (usually glucagon-induced).
Hypoglycemia prevention now occupies center stage in diabetes praxis, as focus moves from a purely efficacy oriented approach to one which aims for safety and tolerability, along with glycemic control. This shift has occurred in parallel with our understanding of the multiple deleterious effects of hypoglycemia on various organ systems; including the heart, brain, and retina.[]
Hypothyroidism is one of the most common endocrinopathies worldwide, and its incidence is increasing rapidly.[] It is frequently found to coexist with both type 1 and type 2 diabetes mellitus.[,] Cross-talk between thyroid and diabetes has been the topic of many reviews, which discuss the potential of hyperthyroidism to exacerbate diabetes,[] and of antidiabetic therapy (metformin) to improve thyroid function.[] The potential role of hypothyroidism in precipitating hypoglycemia has not been highlighted adequately in current literature. This brief communication aims to discuss the link between hypothyroidism and hypoglycemia, and suggest simple caveats for clinical practice.


Interest in the hypoglycemic effect of hypothyroidism began a century ago, even before insulin was discovered.[] Hypothyroidism was, by then, a well-known and well-studied entity, and had been differentiated from hypopituitarism. The hypoglycemia of hypothyroidism, dyspituitarism, and Addison's disease was known to be common knowledge.[] Later, literature clearly highlights the importance of hypothyroidism as a precipitating factor for hypoglycemia, while reporting prolonged hypoglycemia due to exogenously administered insulin in hypothyroid patients.[]
The correlation between diabetes and hyperthyroidism had also been reported before the advent of the insulin era.[] In fact, in his 1947 Nobel lecture, Nobel laureate BA Houssay clearly mentions thyroid as one of the ‘blood sugar raising’ glands (aneterohypophysis, adrenals, thyroid, etc.)[]


Recent literature, however, is conflicting and confusing. Some diabetology textbooks choose not to mention hypothyroidism as a possible factor in the pathogenesis of hypoglycemia, though they do describe Addison's disease and panhypopituitarism.[] Major thyroidology textbooks do not mention susceptibility to hypoglycemia as a complication of hypothyroidism.[] Other modern reviewers, on the other hand, clearly emphasize hypothyroidism as one of the endocrine deficiencies responsible for hypoglycemia.[] Yet others refute this concept, proposing the theory that if hypothyroidism is accompanied by hypoglycemia, it is in fact a manifestation of panhypopituitarism, rather than primary hypothyroid disease.[] Yet others tend to trivialize the issue (‘although seldom happening, hypothyroid patients can experience hypoglycemia’).[]
Yet, case reports have been published which describe the correlation between hypothyroidism and hypoglycemia, both in infants[] and in adults.[] Robust evidence is also available which implicates uncontrolled hyperthyroidism as a cause of poor glycemic control.[]
Is there a physiologic basis to connect hypothyroidism and hypoglycemia? And if we go a step further, can hypothyroidism be postulated as a precipitating factor for hypoglycemia unawareness?


Hypothyroidism is linked with various hormonal biochemical and nervous system abnormalities, which may contribute to hypoglycemia.
The condition is linked with low growth hormone and cortisol responses to insulin induced hypoglycemia, and this prevents adequate counter regulatory protection.[,] It must be noted that in some cases, pituitary dysfunction may be a consequence of primary hypothyroidism, rather than a cause of thyroid dysfunction. For example, hypothyroidism reduces basal and stimulated growth hormone levels, by acting on both the hypothalamus and pituitary.[] As it is linked with suboptimal growth hormone response, the recovery from hypoglycemia may be prolonged in hypothyroidism.
Hypothyroid patients have relative adrenal insufficiency, even if they are not associated with primary adrenal failure. There is a blunted hypothalamo-pituitary-adrenal response to hypoglycemia in hypothyroid persons.[] The reduced cortisol responses to insulin-induced hypoglycemia that are noted in hypothyroidism also worsen hypoglycemia.
The role of gluconeogenesis is reduced in hypothyroidism, both in skeletal muscle and in adipose tissue.[] Glycogenolysis is also impaired in hypothyroidism.[] These biochemical defects lead to a delayed recovery from hypoglycemia.
Other abnormalities in hypothyroidism include a reduction in glucagon secretion,[] reduced effect of glucagon on hepatocytes,[] and slowing of insulin clearance.[] Contributory factors also include the effect of hypothyroidism on the gastro intestinal system. It slows gastric emptying[] and decreases intestinal absorption of glucose as well as portal venous flow.
Modern researchers, on the other hand, have reported the link between subclinical and overt hypothyroidism on one hand, and insulin resistance on the other.[] Reviewers explain this paradox by contrasting the insulin agonist actions of thyroid hormones, evident in peripheral tissues, with insulin antagonist activity in the liver.[] The hepatic effects of thyroxin are mediated directly, as well as through the hypothalamus. Variable effects at peripheral and hepatic levels may explain discordant results obtained by different workers.


The wisdom collated by the pioneers of endocrinology seems to have been lost in modern textbooks. This omission deprives the student of endocrinology of an important clinical practice pearl, viz.: The hypoglycemic side of hypothyroidism. This editorial has tried to highlight a supposedly insignificant aspect of hypothyroidism, which has a significant impact on contemporary diabetology practice. Perhaps the reason for this lack of attention is a lack of clarity regarding the difference between spontaneous hypoglycemia (as seen in panhypopituitarism) and the increased predisposition to hypoglycemia encountered in persons on treatment for diabetes.
The glucoregulatory effects of thyroid hormones carry great clinical significance. Persons with diabetes who report with a sudden increase in frequency or severity of hypoglycemic episodes, not explained by changes in diet, physical activity, or dosage of glucose-lowering drugs, must be evaluated for hypothyroidism.
The symptoms of hypoglycemia may be nonspecific, and may represent subtle neuroglycopenia. A high index of suspicion must be kept in hypothyroid patients on diabetes treatment, as the symptoms of counter regulatory hormone release may be blunted, and there may be an underlying neurocognitive defect in grossly hypothyroid persons.
The clinical implications of the hypoglycemia-prone features of hypothyroidism should be taken into account while planning antidiabetic therapy. Person with uncontrolled hypothyroidism should be given relatively lower doses of insulin and insulin secretagogues (sulfonylureas). Safer insulin analogues which are linked with a lower incidence of hypoglycemia should be preferred.
In patients on treatment for both thyroid disorders and diabetes, thyroid status should be kept in mind while titrating antidiabetic therapy. Those with an improving thyroid status, or falling serum thyroid stimulating hormone (TSH), may require an increase in dosage of antidiabetic medicines. Similarly, those with worsening hypothyroidism will need a reduction in dosage. This down titration will be needed in patients of Graves’ disease who respond rapidly to therapy.
The TSH lowering or potential thyroprotective effect of metformin[] should be considered while assessing thyroid function reports. Above all, one must follow a panglandular approach while managing any endocrine illness, and not neglect the mature wisdom of clinical endocrinology.


Source of Support: Nil

Conflict of Interest: None declared.


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2. Kalra S, Deepak MC, Narang P, Singh V, Uvaraj MG, Agrawal N. Usage pattern, glycemic improvement, hypoglycemia, and body mass index changes with sulfonylureas in real-life clinical practice: Results from OBSTACLE Hypoglycemia Study. Diabetes Technol Ther. 2013;15:129–35. [PubMed]
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4. Kalra S, Kalra B, Chatley G. Prevalence of hypothyroidism in pediatric type 1 diabetes mellitus in Haryana, Northern India. Thyroid Res Pract. 2012;9:12–4.
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7. Kalra S, Dhamija P, Unnikrishnan AG. Metformin and the thyroid: An unexplored therapeutic option. Thyroid Res Pract. 2012;9:75–7.
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19. Wu P. Thyroid disease and diabetes. Clin Diabetes. 2000;18:38–9.
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Articles from Indian Journal of Endocrinology and Metabolism are provided here courtesy of Wolters Kluwer -- Medknow Publications

Monsanto Is Scrambling To Bury This Breaking Story – Don’t Let This Go Unshared!

I am frankly shocked this information is not making front page news right now. Monsanto will do anything to bury this story… and as of right now, it’s working. Not a single mainstream media outlet has covered this appalling new report that shows millions of people being poisoned by a chemical that does not belong in our food. This chemical is ending up in processed foods like Cheerios, Ritz Crackers, and Oreos and being consumed by humans across the world. The health of millions of people is on the line and this news must go mainstream! That’s why I’m calling on every single one of you who reads this post to share this breaking story now. The only way this injustice will be corrected is if enough of us stand up and demand that something be done to stop the poisoning of our food supply.

Share this shocking new report with everyone you know….

A FDA-registered food safety laboratory tested iconic American food for residues of the weed killer glyphosate (aka Monsanto’s Roundup) and found ALARMING amounts.
Just to give you an idea of how outrageous these amounts are, independent research shows that probable harm to human health begins at really low levels of exposure – at only 0.1 ppb of glyphosate. Many foods were found to have over 1,000 times this amount! Well above what regulators throughout the world consider “safe”. 2016-11-14_1536

Here is why we all should be concerned about eating glyphosate:

  • Independent research links glyphosate to cancer (sources: 12345) and it has been deemed a probable human carcinogen by the World Health Organization’s team of international cancer experts. The childhood cancer rate is steadily rising and experts say that they don’t know why. Why are they not taking a closer look at these facts?
  • It binds with vital nutrients in the soil (like iron, calcium, manganese, zinc) and prevents plants for taking them up. Glyphosate is thereby making food less nutritious!

Why is this weed killer in these foods? Even non-GMO and organic food! 

This chemical has gone so mainstream that glyphosate has infiltrated every facet of our environment – our water, air, soil.
  • Glyphosate is not just used on GMOs. Conventional (non-organic farmers) use Roundup as a drying agent on crops, such as oats and wheat. It can’t be simply washed off, as it is taken up into the plant itself.
  • As the active ingredient in popular “Roundup” herbicide, millions of people are using this stuff around their homes, and it’s widely used at parks and other public spaces.
So, that is why it’s not just GMO-filled junk food that is laced with glyphosate. It’s contaminating organic and non-GMO foods, and it’s even in our honey! The FDA quietly found it in almost every single sample of honey that they tested (from mass produced to organic mountain honey). The media has been essentially silent and barely anyone heard this news!
Even if you don’t personally eat the specific brands that were tested (I don’t), how many people are eating Cheerios and Ritz Crackers every day? A lot!

How many of your friends and family have their cabinets filled with these foods? These people need to know this information.

There are still thousands of other brands and whole foods that have not been tested for glyphosate residues, so we can’t be so sure that our own organic, non-GMO, and unprocessed food is safe. Americans are effectively being forced to eat this poison until something is done to stop the rampant use of this chemical. Yes, I said poison.

Monsanto doesn’t want the public to know these findings for obvious reasons. They have our regulatory agencies in their back pocket to make sure they can continue to make a hefty profit while poisoning the masses.

While there are now several manufacturers of glyphosate herbicides, Monsanto completely dominates the market and this is a best seller. They are raking in BILLIONS every year and certainly don’t want that to stop. They are clearly, without a doubt, using their prosperity to influence our government regulators. Why else would those entrusted to protect the public from harmful chemicals turn a blind eye to this?

Our public agencies are allowing corporations to poison Americans for profit.

In 2013, the EPA massively increased the industry standard of what is considered a “safe” level of glyphosate on our food, in order to make enormous amounts seem A-OK. Instead of properly regulating, they effectively raised the “safe” level so that no one can blame the industry for poisoning us with unlawful amounts of chemicals. This is corruption at its finest. The EPA has a long and sordid history of doing whatever Monsanto wants and you have to ask yourself why this continues to happen and how we can make it stop.
The EPA continues to pander to Monsanto, as they keep postponing and dragging their feet to evaluate glyphosate’s link to cancer in humans. The industry is fighting tooth and nail to make sure that the EPA “evaluation” will be in their favor and is trying to control who will be on the panel. Why won’t the EPA do their job to make sure that the world’s most widely used herbicide isn’t causing us all to get cancer? Don’t you think this should be a top priority? It’s time for the EPA to put the public health above the corrupt desires of corporations.
When it comes to the FDA, they are not protecting the American public from glyphosate either. After announcing in February that they would FINALLY begin testing foods for glyphosate residues, they just decided to suspend their testing this week. Could it be that Monsanto didn’t like the results they started getting – especially since the FDA found glyphosate in foods that should be especially safe like BABY FOOD? Monsanto will do whatever it takes to keep that story out of the public eye.

Doesn’t the public deserve to know this information? It should be shouted from the rooftops!

It is shameful that the American media has thus far failed to cover this breaking news, but WE HAVE THE POWER to make this information go viral. If you really want to stop the corruption perpetuated by Monsanto and the large chemical companies – this is how we shut them down!

CALL TO ACTION: Share this post with everyone you know. Tweet, share, and email this information to major media outlets and ask them to cover this story. 

Remember the best way to avoid glyphosate is by choosing certified organic foods because it is prohibited on organic crops. Although contamination is a real threat, the levels on organic foods are minimal compared to what’s been found on conventional foods. It’s been shown that people who eat organic foods have less glyphosate and other synthetic pesticides in their system.
The people of this country must be informed and this should be our top priority. Go, Food Babe Army, Go!

LINK:    >>>>                          iHealthTube.com - The Greatest Medical Hoax in the History of the World " />
Time: 1:14 Added: 1/6/2010
Views: 9291
Dr. Michael Murray explains how we've been misled by drug companies. He looks at statin drugs and why they are not proven to have any real benefit.
Contributor(s): Murray, Michael N.D.
Tags: cholesterol, prescription drugs, statin drugs
The Greatest Medical Hoax in the History of the World Interview with Dr. Michael Murray Interviewed by Lyle Hurd November 13, 2009 Dr. Michael Murray: When all is said and done, the over-reliance on these statin drugs to reduce our risk of heart attacks and strokes will go down as the greatest medical hoax in the history of the world. It’s just appalling and just amazing how we’ve all been misled by the drug company’s propaganda with these statin drugs. And that’s what it is, it masquerades as research that- if you look at the research, these drugs offer very little protection for most people. Eighty percent of the people who are taking these statin drugs are taking them for no good reason. There’s no scientific evidence of any benefit, no reason for them to be taken, these drugs. In 1987, when these drugs were first approved, there were thirteen million Americans with high cholesterol. Now, in 2009, we have over a hundred million Americans with high cholesterol. What happened? The drug companies utilized their influence to lower the level that was considered normal to increase the web that they could cast and haul in more patients.
If you're worried about cholesterol, you should watch this!

Should you consider the Lipitor lawsuit as a result of your diabetes diagnosis?

Current Litigation

Should you consider the Lipitor lawsuit as a result of your diabetes diagnosis?

If you are one of the more than 20 million people that takes statins, such as Lipitor, to control your cholesterol and you developed diabetes, you may be entitled to compensation by filing a Lipitor Lawsuit against the manufacturer, Pfizer.
If you or a loved one was diagnosed with diabetes and believe the diagnosis is the result of their use of Lipitor, our Lipitor Lawyers will be happy to assess your claim with a quick, no charge evaluation to see if you qualify for the Lipitor Diabetes Lawsuit.

Lipitor Diabetes Risk

Lipitor, manufactured by Pfizer, is the most-prescribed medicine in history but several studies now indicate that it is linked to an increased risk of diabetes.
Despite living healthy and active lifestyles, individuals have developed type-2 diabetes after initiating a Lipitor treatment. As a result of a type-2 diabetes diagnosis, individuals find themselves undergoing regular testing of blood glucose levels, adhering to a restrictive diabetic diet and taking medication to control diabetes. Furthermore, individuals diagnosed with diabetes find themselves at a markedly increased risk of heart disease, blindness, neuropathy and kidney disease.
Lipitor diabetes attorneys, TorHoerman Law, believe that despite Pfizer knowing of the Lipitor diabetes risk, Pfizer promoted and marketed Lipitor as safe and effective which resulted in many injured individuals.

When companies put profits ahead of safety, TorHoerman Law believes they should be held responsible for their actions. To that end, the attorneys at TorHoerman Law are offering a no charge, no obligation review of your medical history for potential inclusion in the Lipitor diabetes litigation. We will tell you honestly whether you should consider participation in the Lipitor lawsuit.




The New York Times hailed them as “wonder drugs.” Doctors use them as the first line of defense against heart attack, stroke, inflammation and whatever else they can make sound dreadful and scary. Despite the spin, cholesterol lowering drugs (fibrates and statins) are proving to be not so wonderful. As outlined in the book, Over-The-Counter Natural Cures, by Shane Ellison, MS continuing research showed how these blockbusters failed to prevent heart attack and stroke to any clinical significance. But that’s not the worst part. There’s seems to be a “little” problem with cancer.

    “My husband died last August 2005 of advanced liver cancer (hepatocellular carcinoma). He tested negative for hepatitis and cirrhosis as the common causes of liver cancer. Nothing ever was said about the lovastatin (mevacor) that he was on since 2003 when he had a mild heart attack. A friend (non-M.D.)mentioned the statin probably caused the cancer.”

In their study published in the Journal of the American Medical Association (JAMA), Thomas B. Newman, M.D., MPH, and co-workers show that all cholesterol-lowering drugs, both the early drugs known as fibrates (clofibrate, gemfibrozil) and the newer drugs known as statins (Lipitor, Pravachol, Zocor), cause cancer in rodents at the equivalent doses used by man.
Interestingly, these facts are not reflected in the highly coveted Physicians Desk Reference (PDR) or by the pharmaceutically-compliant media. For instance, the PDR shows that cancer is a side effect for fibric acid derivates and statins only when as much as ten times the recommended human dose is used.
Dr. Gloria Troendle, deputy director for the Division of Metabolism and Endocrine Drug Products for the FDA, noted that the cholesterol-lowering drug gemfibrozil belonged to a class of drugs that has repeatedly been shown to increase death rates among users. Moreover, Dr. Troendle stated that she does not believe the FDA has ever approved a drug for long-term use that was as cancer causing at human doses as gemfibrozil.

Others shared these same concerns about gemfibrozil. In comments to the FDA, Elizabeth Barbehenn, Ph.D., concluded: “fibrates must be considered as potential human carcinogens and their carcinogenic potential should be part of the risk benefit equation for evaluating gemfibrozil.”
Ignoring these facts and despite having a majority vote among their advisory committee against approval, the pharmaceutically- campaigned FDA-approved these drugs anyway! Specifically, when asked to vote whether or not the cholesterol-lowering drug gemfibrozil should be approved for prevention of heart disease, only 3 out of 9 voted in favor of approval. Unfortunately, these votes are only “advisory” and – against the better judgment of the committee – the FDA decided to approve gemfibrozil for human consumption.
Of course, the extrapolation of evidence of cancer from rodent to human is very uncertain. And this is the argument of those who favor using cholesterol-lowering drugs. More likely, such an extrapolation would only hold true if human studies also showed an increase in cancer rates. In fact, that is what scientists are seeing.
Sheperd and colleagues for PROSPER noted in the Lancet that “…new cancer diagnoses were more frequent on pravastatin [Pravachol] than on placebo [those not taking the drug].” Similar findings were made in the CARE (Cholesterol And Recurrent Events) trial. Evidence from the trial showed a significant increase (a 1500% relative risk increase) in breast cancer among women taking Pravachol (a cholesterol-lowering drug made by Bristol-Myer Squib).
One mechanism by which cholesterol-lowering drugs may cause cancer has been identified. Published in Nature Medicine, Dr. Michael Simons of Beth Israel Deaconess Medical Center in Boston shows that statin drugs mimic a substance known as vascular endothelial growth factors (VEGF). The biochemical VEGF promotes the growth of new blood vessels, a process known as angiogenesis. While angiogenesis may help the growth of arteries, the benefit is quickly negated by the potential for growth of cancer.
The British Journal of Cancer reports that VEGF plays an important role in the spread of colorectal cancer. Further, for those who already have tumors, VEGF and compounds that mimic VEGF significantly diminish that person’s survival time.
The fact that cholesterol-lowering drugs can potentially cause cancer at doses commonly used by humans will never be accepted as mainstream knowledge. Drug company-funded studies for cholesterol-lowering drugs are conveniently short in nature, typically five years or less. It takes decades for cancer to develop. Actually, even heavy smoking will not cause lung cancer within five years. Yet it is a well-known fact that smoking leads to lung cancer. Therefore, as long as statin drug trials last only five years, the fact that these “wonder drugs” aren't wonder drugs will continue to fly below the radar.
By now, most people are starting to see the big picture – wonder drugs aren't that wonderful. Stop fearing your cholesterol levels and starting taking charge of your own health.
By: Shane Ellison, MS


Immune System Restoration

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“Incurable” Diseases can now be HEALED!
Chronic Autoimmune Conditions can now be eliminated by restoring ACCURACY to the IMMUNE SYSTEM, and allowing IMMUNITY to heal the body. By Dr. Ronald P. Drucker See list of autoimmune conditions here.

This is an immune killer cell. Its job is to hunt down and eliminate harmful pathogens (germs) in our bodies. The fuzzy coating surrounding the cell is known as the Glycocalyx. The Glycocalyx functions as a coding system (a guidance system) which enables the immune cells to communicate with other cells in order to find the pathogens, and eliminate them. This guidance system is made up of Immune Modulating Components (IMCs) of multiple types. Think of it this way; IMCs function like a “GPS SYSTEM” for Immune Killer Cells, so that they may HIT their target, the germ or pathogen.
Immune Killer Cell

When IMCs are present in the body in adequate supply, the immune killer cells become very ACCURATE, able to find and eliminate the pathogens which promote illness and disease.


When IMCs are NOT present in the body, the immune cells become very INACCURATE, often unable able to find the pathogens, often attacking the tissues of the body instead! This is Autoimmunity. Autoimmunity is the Failure of the immune system to differentiate or recognize the body’s cells from the pathogens always present within the body. As a result, the immune killer cells often attack the cells, tissues, and organs of the body, causing damage and disease. See list of autoimmune conditions here.

ACCURATE immune cells keep us Healthy by eliminating pathogens.
INACCURATE immune cells cause damage and disease by attacking the body, not the pathogen.

So what happened to the IMCs in our modern-day food supply?

Fruit trees and vegetable plants can only produce IMCs when the soil is rich with minerals. As the Minerals in our soils have been progressively depleted, so too have the IMCs, and as a result; Autoimmune Diseases have progressively Risen. See charts below.

The soils no longer contain the minerals required for the crops to produce immune modulating components required by the human immune system. The increasing result on the population is immune failure and the rise of Autoimmune Diseases.

The Solution

As confirmed by the nation’s top Immune restoration practitioners; by ingesting high concentrations of immune modulating components, the immune system can restore to accurate immune function, thus eliminating the inaccurate autoimmune attack which is the driving force behind autoimmune conditions.

By far the best source of IMC’s is an organic growing operation producing a product known as DigestaCure AUTOIMMUNE-X® which is a high concentration of All Natural Immune Modulating Components researched, developed, and tested for over 20 years. No prescription is required.
Recapping: By feeding the immune system what it is lacking, IMCs, the immune killer cells can be restored to accurate function, once again able to locate and eliminate the pathogen, rather than missing the pathogen, and striking the cells, organs, and tissues of the body.
The autoimmune attack on various locations within the body, is the root-cause of over 100 autoimmune conditions. See list of autoimmune conditions here.
To understand more you may read my free book here; www.thecodeoflife.info

Could a probiotic pill cure diabetes?

Published Published Mon 2 Feb 2015

More than 29 million people in the US have diabetes, and it is the seventh-leading cause of death in the country. But could a cure be on the horizon? According to researchers from Cornell University in Ithaca, NY, it could - in the form of a probiotic pill.
A reprogrammed rat cell
Using engineered human gut bacteria, researchers were able to reprogram the cells of diabetic rats to produce insulin. Pictured is a reprogrammed rat cell; the green coloring shows insulin.
Image credit: Diabetes journal/Cornell University
In a proof-of-principle study published in the journal Diabetes, senior author John March and colleagues from Cornell reveal how they were able to reduce blood glucose levels in diabetic rats using a common bacteria found in the human gut.
Diabetes is a condition in which the pancreas is either unable to produce enough of the hormone insulin, the body's cells do not effectively respond to the hormone, or both.
As a result, blood glucose levels rise higher than normal - known as hyperglycemia. This can cause a number of complications, including stroke, heart disease and nerve damage.
Diabetes prevalence has risen in the US in recent years, increasing from 25.8 million people affected in 2010 to 29.1 million in 2012.
But with the findings of their study, March and colleagues say they may be one step closer to a cure for the condition.
The researchers engineered a common strain of "friendly" human gut bacteria called Lactobacillus to secrete Glucagon-like peptide 1 (GLP-1) - a hormone that releases insulin in response to food.
Lactobacillus is a probiotic often used to prevent and treat diarrhea, as well as irritable bowel syndrome (IBS), Crohn's disease and some skin disorders.

Engineered probiotic reduced blood glucose levels by up to 30%

Each day for 90 days, the team orally administered the modified probiotic to a group of diabetic rats. They monitored its effects on blood glucose levels, comparing the outcomes with diabetic rats that did not receive it.
At the end of the 90 days, the researchers found the rats that received the modified probiotic had blood glucose levels up to 30% lower than those that did not receive the probiotic.
The team says the probiotic appeared to convert the rats' upper intestinal epithelial cells to cells that acted a lot like pancreatic beta cells, which - in healthy people - secrete insulin and regulate blood glucose levels.
March adds:
"The amount of time to reduce glucose levels following a meal is the same as in a normal rat, and it is matched to the amount of glucose in the blood, just as it would be with a normal-functioning pancreas. It's moving the center of glucose control from the pancreas to the upper intestine."
On giving the modified probiotic to healthy rats, however, the team found that it did not appear to affect blood glucose levels. "If the rat is managing its glucose, it doesn't need more insulin," says March.
The team says they now plan to test higher doses of the engineered probiotic in diabetic rats in order to see whether it can completely reverse the condition.
They are also working with a biopharmaceutical company called BioPancreate to get the probiotic made into a pill for human use. If successful, the researchers say it would be likely a diabetic would take the pill each morning to help manage their condition.
In November 2014, Medical News Today reported on a study suggesting a common blood pressure drug may completely reverse diabetes.

5 Steps to Kill Hidden Bad Bugs in Your Gut that Make You Sick

DOCTORS ARE TRAINED TO IDENTIFY DISEASES by where they are located. If you have asthma, it’s considered a lung problem; if you have rheumatoid arthritis, it must be a joint problem; if you have acne, doctors see it as a skin problem; if you are overweight, you must have a metabolism problem; if you have allergies, immune imbalance is blamed. Doctors who understand health this way are both right and wrong. Sometimes the causes of your symptoms do have some relationship to their location, but that’s far from the whole story.
As we come to understand disease in the 21st century, our old ways of defining illness based on symptoms is not very useful. Instead, by understanding the origins of disease and the way in which the body operates as one, whole, integrated ecosystem, we now know that symptoms appearing in one area of the body may be caused by imbalances in an entirely different system.
If your skin is bad or you have allergies, can’t seem to lose weight, suffer from an autoimmune disease or allergies, struggle with fibromyalgia, or have recurring headaches, the real reason may be that your gut is unhealthy. This may be true even if you have NEVER had any digestive complaints.
There are many other possible imbalances in your body’s operating system that may drive illness, as well. These include problems with hormones, immune function, detoxification, energy production, and more. But for now, let’s take a deeper look at the gut and why it may be at the root of your chronic symptoms.
Symptoms Throughout the Body Are Resolved By Treating the Gut
Many today do have digestive problems including reflux or heartburn, irritable bowel, bloating, constipation, diarrhea, and colitis. In fact, belly problems account for over 200 million doctor’s visits and billions in health care costs annually. But gut problems cause disease far beyond the gut. In medical school, I learned that patients with colitis could also have inflamed joints and eyes and that patients with liver failure could be cured of delirium by taking antibiotics that killed the toxin-producing bacteria in their gut. Could it be that when things are not quite right down below, it affects the health of our entire body and many diseases we haven’t linked before to imbalances in the digestive system?
The answer is a resounding yes. Normalizing gut function is one of the most important things I do for patients, and it’s so simple. The “side effects” of treating the gut are quite extraordinary. My patients find relief from allergies, acne, arthritis, headaches, autoimmune disease, depression, attention deficit, and more—often after years or decades of suffering. Here are a few examples of the results I have achieved by addressing imbalances in the function and flora of the gut:
  • A 58-year-old woman with many years of worsening allergies, asthma, and sinusitis who was on frequent antibiotics and didn’t respond to any of the usual therapies was cured by eliminating a worm she harbored in her gut called Strongyloides.
  • A 52-year-old woman who suffered with daily headaches and frequent migraines for years, found relief by clearing out the overgrowth of bad bugs in her small intestine with a new non-absorbed antibiotic called Xifaxin.
  • A six-year-old girl with severe behavioral problems including violence, disruptive behavior in school, and depression was treated for bacterial yeast overgrowth, and in less than 10 days, her behavioral issues and depression were resolved.
  • A three-year-old boy with autism started talking after treating a parasite called Giardia in his gut.
These are not miracle cures but common results that occur when you normalize gut function and flora through improved diet, increased fiber intake, daily probiotic supplementation, enzyme therapy, the use of nutrients that repair the gut lining, and the direct treatment of bad bugs in the gut with herbs or medication.
A number of recent studies have made all these seemingly strange reversals in symptoms understandable. Let’s review them.
Research Linking Gut Flora and Inflammation To Chronic Illness
Scientists compared gut flora or bacteria from children in Florence, Italy who ate a diet high in meat, fat, and sugar to children from a West African village in Burkina Faso who ate beans, whole grains, vegetables, and nuts.(i) The bugs in the guts of the African children were healthier, more diverse, better at regulating inflammation and infection, and better at extracting energy from fiber. The bugs in the guts of the Italian children produced by-products that create inflammation, promote allergy, asthma, autoimmunity, and lead to obesity.
Why is this important?
In the West, our increased use of vaccinations and antibiotics and enhancements in hygiene have lead to health improvements for many. Yet these same factors have dramatically changed the ecosystem of bugs in our gut, and this has a broad impact on health that is still largely unrecognized.
There are trillions of bacteria in your gut, and they collectively contain at least 100 times as many genes as you do. The bacterial DNA in your gut outnumbers your own DNA by a very large margin. This bacterial DNA controls immune function, regulates digestion and intestinal function, protects against infections, and even produces vitamins and nutrients.
Can bacteria in the gut actually affect the brain? They can. Toxins, metabolic by-products, and inflammatory molecules produced by these unfriendly bacteria can all adversely impact the brain.
When the balance of bacteria in your gut is optimal, this DNA works for you to great effect. For example, some good bacteria produce short chain fatty acids. These healthy fats reduce inflammation and modulate your immune system. Bad bugs, on the other hand, produce fats that promote allergy and asthma, eczema, and inflammation throughout your body.(ii)
Another recent study found that the bacterial fingerprint of gut flora of autistic children differs dramatically from healthy children.(iii) Simply by looking at the by-products of their intestinal bacteria (which are excreted in the urine—a test I do regularly in my practice called organic acids testing), researchers could distinguish between autistic and normal children.
Think about this: problems with gut flora are linked to autism. Can bacteria in the gut actually affect the brain? They can. Toxins, metabolic by-products, and inflammatory molecules produced by these unfriendly bacteria can all adversely impact the brain. I explore the links between gut function and brain function in much greater detail in my book, The UltraMind Solution.
Autoimmune diseases are also linked to changes in gut flora. A recent study showed that children who use antibiotics for acne may alter normal flora, and this, in turn, can trigger changes that lead to autoimmune disease such as inflammatory bowel disease or colitis.(iv)
The connections between gut flora and system-wide health don’t stop there. A recent study in the New England Journal of Medicine found that you could cure or prevent delirium and brain fog in patients with liver failure by giving them an antibiotic called Xifaxan to clear out bugs that produce toxins their poor livers couldn’t detoxify.(v) Toxins from bacteria were making them insane and foggy. Remove the bacteria that produce the toxins, and their symptoms clear up practically overnight.
Other similar studies have found that clearing out overgrowth of bad bugs with a non-absorbed antibiotic can be an effective treatment for restless leg syndrome(vi) and fibromyalgia.(vii)
Even obesity has been linked to changes in our gut ecosystem that are the result of a high-fat, processed, inflammatory diet. Bad bugs produce toxins called lipopolysaccardies (LPS) that trigger inflammation and insulin resistance or pre-diabetes and thus promote weight gain.(viii)
It seems remarkable, but the little critters living inside of you have been linked to everything from autism to obesity, from allergy to autoimmunity, from fibromyalgia to restless leg syndrome, from delirium to eczema to asthma. In fact, the links between chronic illness and gut bacteria keep growing every day.
So what can you do to keep your gut flora balanced and your gut healthy, and thus overcome or avoid these health problems?
Five Steps to a Healthy Gut (and a Healthy Body)
Follow these five simple steps to begin re-balancing your gut flora:
  1. Eat a fiber–rich, whole foods diet—it should be rich in beans, nuts, seeds, whole grains, fruits, and vegetables, all of which feed good bugs.
  2. Limit sugar, processed foods, animal fats, and animal protein—these provide food for unhealthy bugs.
  3. Avoid the use of antibiotics, acid blockers, and anti-inflammatories—they change gut flora for the worse.
  4. Take probiotics daily—these healthy, friendly flora can improve your digestive health and reduce inflammation and allergy.
  5. Consider specialized testing—such as organic acid testing, stool testing (new tests can look at the DNA of the bacteria in your gut), and others to help assess your gut function. You will likely have to work with a functional medicine practitioner to effectively test and treat imbalances in your gut.
And if you have a chronic illness, even if you don’t have digestive symptoms, you might want to consider what is living inside your gut. Tending to the garden within can be the answer to many seemingly unrelated health problems.